Titelblatt von Cell, vol. 153(1); 28. März 2013:
Dazu heißt es:
The kind of food an organism consumes has a broad reaching impact on its development, behavior, and lifespan. In this issue, two papers, MacNeil et al. (pp. 240–252) and Watson et al. (pp. 253–266), explore the effects of diet on these life-history traits in the nematode C. elegans. Combining nutrigenomics and network analyses, they find that different diets affect traits via distinct mechanisms. The response to diet is coupled to metabolic changes, and disruptions of some of these specific metabolic pathways correspond to inborn errors of metabolism in humans. The cover features a “native-art-inspired abstraction” of a worm eating a bacterial diet and illustrates the interconnectedness between diet, nuclear gene regulatory networks, mitochondrial networks, and their effects on life-history traits such as development and brood size.
Cover art by Lesley T. MacNeil.
Caenorhabditis elegans — das ist bekannt — dient vor allem Entwicklungsbiologen als eines ihrer liebsten „Haustiere“. Allerdings war es bisher sehr mühsam, die Würmchen nach diversen Entwicklungsstadien zu sortieren. Nach Augenmaß und mit Mundpipette verteilten die Wurmfoscher sie meist in verschiedene Töpfchen. Und dann, so berichtet der Berliner Doktorand Marlon Stoeckius vom 
