The Hannover Medical School (MHH), founded in 1965, is a site of excellence for biomedical research in Germany. Our research and patient care sets national and international standards. We are also part of regional biomedical networks for achieving outstanding interdisciplinary translational science.


Postdoctoral position: Generation of novel human antibodies in humanized mice

This full-time position at the MHH is initially funded for two years. Deadline for applications is 31st of March 2019. Desirable start date is 1st of April 2019, but late applications will be considered until the position is filled.

This postdoctoral position is financed by the “German Center for Infection Research”
(DZIF) in the program area of “Infections of the Immunecompromised Host” (IICH) (http://www.dzif.de/forschung/infektionen_im_immungeschwaechten_wirt/). 

The research will be conducted as a collaboration of the MHH - Regenerative Immune Therapy Applied Laboratory (Prof. Renata Stripecke) with the MHH - Department of Virology (Prof. Martin Messerle/Prof. Thomas Krey) and the Helmholtz Zentrum München - Research Unit Gene Vectors (Prof. Reinhard Zeidler). Using novel technologies, the consortium will use mice reconstituted with a human immune system to generate novel monoclonal antibodies protective against human Cytomegalovirus (HCMV) or Epstein Barr Virus (EBV).

Your task:

The main task of the postdoc is to optimize the technology for generation of human antibodies in humanized mice using antigen-targeted B cell sorting assays, single cell RNA sequencing, gene amplification, library screenings and cloning. The postdoc will co-manage the other staff participating in the project and coordinate the interactions with the other DZIF collaborative partners in order to reach the defined targets within the calculated time and budget. The postdoc will report to the consortium partners and write reports and manuscripts.

Qualifications:

PhD or MD/PhD title obtained within last 3 years, qualified for experiments with mice (FELASA B
certificate), team leading communication and reporting skills and strong publication record. Candidates (m/f) should have demonstrated solid previous experience with: Mouse handling (human hematopoietic stem cell transfer, virus infections, immunizations, collection of tissues, optical imaging analyses, preparation of tissues for histology), immunologic analyses (multicolor flow cytometry for characterization of human T and B cells, IgG ELISA and ELISpot, antibody neutralization assays), molecular biology (lentiviral vector construction and production, single cell RNA sequencing), bioinformatics (BCR repertoire analyses in silico, analyses of CDR, VH and VL sequences). Excellent organizational skills, initiative, responsibility, team-work mentality, fluency (verbal and written) in English and German, experience in writing animal study protocols, computer skills for data analyses and presentation and reports.

Compensation:
The salary ranking will be based on the university pay scheme for researchers (m/f) and will be commensurate with qualifications (up to 100 % TV-L 13 – 38.5 hours per week). The Hannover Medical School is an equal opportunity employer. Qualified women are therefore particularly encouraged to apply. Applicants (m/f) with disabilities are treated with preference given comparable qualification.

If you are interested in applying, send by email a cover letter explaining your motivation, CV, certificates and names of 3 persons able to provide reference letters to:

 

Prof. Dr. Renata Stripecke, stripecke.lab@mh-hannover.de

Please do not send paper applications with original documents.

 

zertifikat
zertifikat