The German Cancer Re­search Center is the largest bio­medi­cal re­search insti­tu­tion in Germany. With more than 3,000 em­ployees, we operate an exten­sive scien­tific program in the field of cancer research.

The Division of Signal Transduction and Growth Control is seeking a


(Ref-No. 2019-0268)

Chronic inflammation is a main driver of the development of hepatocellular carcinoma (HCC), one of the most frequent and dismal human malignancies. Employing mouse models of inflammation-driven cancer including squamous cell carcinoma and HCC, our division has identified the receptor RAGE and its ligands, the damage molecular pattern (DAMP) molecules S100A8/A9 and HMGB1 as important players of chronic inflammation and cancer development (Gebhardt et al., 2008, J Exp Med 205:275-85; Nemeth et al., 2009, Hepatology 50:1251-62; Wiechert et al., 2012, Cell Comm Signal, 10:40; Pusterla et al., 2013, Hepatology, 58:363-73; de Ponti et al., 2015, Cancer Letters 369: 396-404; de Ponti et al., 2015 Int J Cancer 136:2458-63). 


The current project aims at analysing the function of the receptor RAGE in liver progenitor cells during acute and chronic liver damage, hepatitis and develop­ment and progression of liver cancer. The candidate will apply gain-of-function and loss-of-function approaches in genetically modified mice and in vitro cell cultures to define the role of this molecule in chronic liver damage, inflam­mation, tumor cell formation and invasion using state-of-the-art transgenic and global gene expression technologies.

This project is part of the DFG funded research consortium TR-209 “Liver cancer” (

Your profile:

We are looking for a highly motivated and ambitious postdoc with a Ph.D. to complement our team. The candidate should have a strong background in molecular and cellular biology demonstrated by peer-reviewed publications and a strong interest in liver tumor biology. Excellent experimental and analytical skills in advanced cell culture techniques and mouse genetics including animal experimentation are mandatory. Familiarity with multi-omics datasets are a plus.

The German Cancer Research Center is committed to increase the percentage of female scientists and encourages female applicants to apply. Among candidates of equal aptitude and qualifications, a person with disabilities will be given preference.

To apply for a position please use our online application portal (

We ask for your understanding that we cannot return application documents that are sent to us by post (Deutsches Krebs­forschungs­zentrum, Personal­abteilung, Im Neuen­heimer Feld 280, 69120 Heidelberg) and that we do not accept applications submitted via email. We apolo­gize for any inconvenience this may cause.

Deutsches Krebsforschungszentrum (DKFZ)
2019-08-27T22:00:00Z FULL_TIME
YEAR null
Heidelberg 69120 Im Neuenheimer Feld 280
49.414414 8.672960699999999